What it is claimed to help
These are the uses attached to TB-500 in research, clinical practice, or marketing. Listing a claim is not endorsing it — tap any of them to see every other compound carrying the same claim.
What the human evidence actually is
Preclinical animal and cell work. No meaningful human evidence.
None for the fragment. The cardiac and repair research people cite used full-length thymosin β4 — 43 amino acids — in mice, not the short fragment sold as TB-500. Full Tβ4 did reach human trials for dry eye and pressure ulcers; the intravenous cardiac programme never published efficacy results. For cardiac repair in humans: zero data either way.
How it is supposed to work
The LKKTETQ actin-binding region promotes cell migration and angiogenesis in animal models.
Safety
No human safety data for the fragment. Prohibited in sport and detectable.
Storage and handling
Lyophilised peptide is generally stored at 2–8 °C, or below −20 °C for long-term storage. Reconstituted in bacteriostatic water (0.9% benzyl alcohol) a solution is typically treated as usable for about 28 days refrigerated, versus roughly 24 hours for plain sterile water, which has no preservative. Add the water slowly down the vial wall and swirl — never shake, which shears peptide chains and foams the solution.
Whatever number a protocol or a prescriber gave you, converting it into syringe units is where a misplaced decimal becomes a tenfold error. Our calculators do that conversion and nothing else — they never invent a dose.
Open the calculatorsSources
- Bock-Marquette I et al. Thymosin β4 and cardiac repair, Nature 2004
- RegeneRx clinical programme disclosures
- FDA PCAC briefing document, July 2026
- WADA Prohibited List
Verified against primary sources on 27 August 2026. Regulatory status in this field changes several times a year. See How We Rate Evidence.